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Timothy A. Bell , Elena de la Casa-Esperón , Heather E. Doherty , Folami Ideraabdullah , Kuikwon Kim , Yunfei Wang , Leslie A. Lange , Kirk Wilhemsen , Ethan M. Lange , Carmen Sapienza and Fernando Pardo-Manuel de Villena
Genetics January 1, 2006 vol. 172 no. 1 411-423; https://doi.org/10.1534/genetics.105.047118
Timothy A. Bell
Elena de la Casa-Esperón
Heather E. Doherty
Folami Ideraabdullah
Kuikwon Kim
Yunfei Wang
Leslie A. Lange
Kirk Wilhemsen
Ethan M. Lange
Carmen Sapienza
Fernando Pardo-Manuel de Villena

Abstract

The DDK syndrome is an early embryonic lethal phenotype observed in crosses between females of the DDK inbred mouse strain and many non-DDK males. Lethality results from an incompatibility between a maternal DDK factor and a non-DDK paternal gene, both of which have been mapped to the Ovum mutant () locus on mouse chromosome . Here we define a 465-kb candidate interval for the paternal gene by recombinant progeny testing. To further refine the candidate interval we determined whether males from 17 classical and wild-derived inbred strains are interfertile with DDK females. We conclude that the incompatible paternal allele arose in the lineage and that incompatible strains should share a common haplotype spanning the paternal gene. We tested for association between paternal allele compatibility/incompatibility and 167 genetic variants located in the candidate interval. Two diallelic SNPs, located in the gene cluster, are completely predictive of the polar-lethal phenotype. These SNPs also predict the compatible or incompatible status of males of five additional strains.

Footnotes

Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under accession nos. AM056072 Havaianas Origine Slim Shine Espadrille UNEYKWb
and AM075608 AM075620 .

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History
BY Matt Soniak
March 7, 2018
iStock

In the 18th and 19th centuries, the Western world worked itself up into a mass hissy fit over the idea of people touching themselves. Judeo-Christian tradition had already been damning masturbation as a misuse of sexuality for ages, but Victorian era prudishness and the Great Awakening and other religious revivals in America created a perfect storm for people to really get obsessed with it.

Books like the anonymously authored Ononia: Or the Heinous Sin of Self-Pollution, and all its Frightful Consequences... and Samuel Tissot's Treatise on the Diseases Produced by Onanism [masturbation]laid the groundwork for medicalizing “the solitary vice.” Soon, masturbation was no longer just a moral failing, but also a physical and mental ailment that required treatment and cures.

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In the young United States, one of the loudest anti-masturbation voices was a Michigan physician named John Harvey Kellogg. The good doctor was a bit uncomfortable about sex, thinking it detrimental to physical, emotional, and spiritual well-being. He personally abstained from it, and never consummated his marriage (and may have actually spent his honeymoon working on one of his anti-sex books). He and his wife kept separate bedrooms and adopted all of their children.

Sex with your wife was bad, but masturbation was even worse. “If illicit commerce of the sexes is a heinous sin,” Kellogg wrote, “self-pollution is a crime doubly abominable.” In Plain Facts for Old and Young: Embracing the Natural History and Hygiene of Organic Life , Kellogg cataloged 39 different symptoms of a person plagued by masturbation, including general infirmity, defective development, mood swings, fickleness, bashfulness, boldness, bad posture, stiff joints, fondness for spicy foods, acne, palpitations, and epilepsy.

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